Many of the following publications are available through the MEDLINE database via PubMed. Click on a publication to link to the corresponding online journal.

2007

55. Patel S, Kurpinski K, Quigley R, Gao HF, Hsiao BS, Poo MM, and Li S. (2007) Bioactive nanofibers: Synergistic effects of nanotopography and chemical signaling on cell guidance. Nano Letters

54. Hashi C, Zhu Y, Yang GY, Young WL, Hsiao B, Chu B, and Li S, Anti-thrombogenic property of bone marrow mesenchymal stem cells in nanofibrous vascular grafts," Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11915-20.

53. Park JS, Huang NF, Kurpinski KT, Patel S, Hsu S, Li S (2007) Mechanobiology of mesenchymal stem cells and their use in cardiovascular repair. Frontiers of Bioscience (In press)

52. Mai JY, Sun C, Li S and Zhang X (2007) A microfabricated platform probing cytoskeleton dynamics using multidirectional topographical cues. Biomedical Microdevices May 22 [Epub ahead of print]

51. Wang Y, Chang J, Chen KD, Li S, Li JY, Wu C, Chien S. (2007) Selective adapter recruitment and differential signaling networks by VEGF vs. shear stress. Proc Natl Acad Sci U S A. May 11; [Epub ahead of print]

50. Patel S, Tsang J, Harbers G, Healy K, Li S (2007) Regulation of endothelial cell function by GRGDSP peptide grafted on interpenetrating polymers. J of Biomaterials Res A Apr 23; [Epub ahead of print]

49. Huang NF, Lee R, Li S (2007) Chemical and Physical Regulation of Stem Cells and Progenitor Cells: Potential for Cardiovascular Tissue Engineering. Tissue Eng Mar 8; [Epub ahead of print]

2006

48. Kurpinski K, Chu J, Hashi, C, Li S (2006) Anisotropic mechanosensing by mesenchymal stem cells. Proc Natl Acad Sci U S A. 103(44): 16095-16100.

47. Huang NF, Patel S, Thakar RG, Wu J, Hsiao BS, Chu B, Lee RJ, Li S (2006) Myotube Assembly on Nanofibrous and Micropatterned Polymers. Nano Letters 6(3): 537-542.

46. Huang NF, Sievers RE, Park JS, Fang Q, Li S, Lee RJ (2006) A Rodent Model of Myocardial Infarction for Testing the Efficacy of Cells and Polymers for Myocardial Reconstruction. Nature Protocol 1(3): 1596-1609.

45. Patel S, Thakar R, Wong J, McLeod SD, Li S (2006) Control of cell adhesion on poly(methyl methacrylate). Biomaterials 27(14): 2890-2897.

44. Kurpinski K, Park J, Thakar R, and Li S (2006) Regulation of Vascular smooth muscle cells and Mesenchymal Stem Cells by Mechanical Strain. Molecular and Cellular Biomechanics 3(1): 11-24.

43. Eastman PS, Ruan W, Doctolero M, Nuttall R, de Feo G, Park PS, Chu JSF, Cooke P, Gray JW, Li S, Chen FF (2006) Qdot Nanobarcodes for Multiplexed Gene Expression Analysis. Nano Letters 6(5) 1059-1064.

42. Hsu S, Thakar R and Li S (2006) Haptotaxis of endothelial cell migration under flow. In: Methods in Molecular Biology. (In press)

2005

41. Moon J, Matsumoto M, Shyam P, Lee L, Guan JL, and Li S. (2005) The role of cell surface heparan sulfate proteoglycans in endothelial cell migration and mechanotransduction. J Cell Physiol 203(1): 166-176.

40. Chien, S, Li S, Shiu, YT, and Li YS. (2005) Molecular basis of mechanical modulation of endothelial cell migration. Front Biosci. 10:1985-2000.

39. Li S, Guan JL, and Chien S. (2005) Biochemistry and biomechanics of cell motility. Annu Rev Biomed Eng 7:105-150.

38. Huang NF, Yu J, Sievers R, Li S, Lee RJ. (2005) Injectable biopolymers enhance angiogenesis after myocardial Infarction. Tissue Eng 11: 1860-1866.

37. Hsu S, Thakar R, Liepmann D, and Li S (2005) Effects of fluid shear stress on vascular endothelial cell haptotaxis on micropatterned surfaces. Biochem Biophys Res Commun 337(1): 401-409.

36. Li S, Huang NF, Hsu S. (2005) Mechanotransduction in endothelial cell migration. J Cell Biochem. 966(6): 1110-1126.

35. Mai W, Chen D, Ding T, Kim I, Park S, Cho SY, Chu JS, Liang D, Wang N, Wu D, Li S, Zhao P, Zent R, Wu G. (2005) Inhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells. Mol Biol Cell. 16(9):4398-409.

34. Li S. (2005) Analysis of endothelial cell migration under flow. In: Methods in Molecular Biology. 294:107-21

33. Li S, Lindahl A, Nannmark U and Chien S (2005) Interactions between bone marrow stem cells and extracellular matrix in bone and cartilage. In: The Osseointegration Book: From Calvarium to Calcaneus. . Quintessence Publishing Co, Inc.

2004

32. Wang D, Park JS, Chu JS, Krakowski A, Luo K, Chen DJ, Li S. (2004) Proteomic profiling of bone marrow mesenchymal stem cells upon TGF-Beta stimulation. J Biol Chem. 279(42):43725-43734.

31. Park J, Chu J, Cheng C, Chen F, Chen DJ, and Li S. (2004) Differential effects of equiaxial and uniaxial strains on mesenchymal stem cells. Biotechnology and Bioengineering (Special Issue on Stem Cell Engineering) 14;88(3):359-368.

30. Shiu YT, Li S, Marganski WA, Usami S, Schwartz MA, Wang YL, Dembo M, Chien S. (2004) Rho mediates the shear-enhancement of endothelial cell migration and traction force generation. Biophys J.86:2558-65.

29. Yang XB, Bhatnagar RS, Li S, and Oreffo ROC. (2004) Biomimetic collagen scaffolds for human bone cell growth & differentiation. Tissue Eng 10(7-8):1148-59.

28. Zhang MZ, Mai W, Li C, Cho SY, Hao C, Moeckel G, Zhao R, Kim I, Wang J, Xiong H, Wang H, Sato Y, Wu Y, Nakanuma Y, Lilova M, Pei Y, Harris RC, Li S, Coffey RJ, Sun L, Wu D, Chen XZ, Breyer MD, Zhao ZJ, McKanna JA, Wu G. (2004) PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proc Natl Acad Sci USA.101:2311

2003

27. Li S, Lao J, Chen BP, Li YS, Zhao Y, Chu J, Chen KD, Tsou TC, Peck K, Chien S. (2003) Genomic analysis of smooth muscle cells in 3-dimensional collagen matrix. Faseb J.17:97-9.

26. Shiu YT, Li S, Yuan SL, Wang YX, Nguyen P, Chien S. (2003) Shear stress-induced c-fos activation is mediated by Rho in a calcium-dependent manner. Biochem Biophys Res Commun. 303:548-555.

25. Li S, Moon JJ, Miao H, Jin G, Chen BP, Yuan S, Hu Y, Usami S, Chien S. (2003) Signal Transduction in Matrix Contraction and the Migration of Vascular Smooth Muscle Cells in Three-Dimensional Matrix. J Vasc Res.40:378-388.

24. Thakar RG, Ho F, Huang NF, Liepmann D, Li S. (2003) Organization and regulation of vascular smooth muscle cells by micropatterning. Biochem Biophys Res Commun.307:883-890.

23. Nguyen H, Qian JJ, Bhatnagar RS, Li S. (2003) Enhanced cell attachment and osteoblastic activity by P-15 peptide-coated matrix in hydrogels. Biochem Biophys Res Commun.311:179-86.

2002

22. Li S, Butler P, Wang Y, Hu Y, Han DC, Usami S, Guan JL, Chien S. (2002) The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. Proc Natl Acad Sci U S A.99:3546-51.

21. Miao H, Li S, Hu YL, Yuan S, Zhao Y, Chen BP, Puzon-McLaughlin W, Tarui T, Shyy JY, Takada Y, Usami S, Chien S. (2002) Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling. J Cell Sci.115:2199-206.

20. Tzima E, Del Pozo MA, Kiosses WB, Mohamed SA, Li S, Chien S, Schwartz MA. (2002) Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression. Embo J.21:6791-800.

19. Hu YL, Li S, Miao H, Tsou TC, del Pozo MA, Chien S. (2002) Roles of microtubule dynamics and small GTPase rac in endothelial cell migration and lamellipodium formation under flow. Journal of Vascular Research.39:465-476.

18. Wang Y, Miao H, Li S, Chen KD, Li YS, Yuan S, Shyy JY, Chien S. (2002) Interplay between integrins and FLK-1 in shear stress-induced signaling. Am J Physiol Cell Physiol.283:C1540-7.

2001

17. Li S, Bhatia S, Hu YL, Shiu YT, Li YS, Usami S, Chien S. (2001) Effects of morphological patterning on endothelial cell migration. Biorheology.38:101-108.

16. Chen BP, Li YS, Zhao Y, Chen KD, Li S, Lao J, Yuan S, Shyy JY, Chien S. (2001) DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress. Physiol Genomics.7:55-63.

15. Hsu PP, Li S, Li YS, Usami S, Ratcliffe A, Wang X, Chien S. (2001) Effects of flow patterns on endothelial cell migration into a zone of mechanical denudation. Biochem Biophys Res Commun.285:751-9.

1990-2000

14. Chien S and Li S, (2000) Biomolecular Engineering of Osseointegration. In: Osseointegration: From Molecule to Man. ed. by Williams E, Rydevik B and Branemark P-I. Optimaltryck, Sweden, pp13-16.

13. Shyy JY, Li YS, Li S, Jalali S, Kim M, and Chien S. (1999) Protein phosphorylation in shear stress activated endothelial cells. In: Mechanical Forces and Endothelium. ed. by Lelkes PI, Harwood Academic Publishers, Reading, UK, pp 69-87.

12. Li S, Chen BP, Azuma N, Hu YL, Wu SZ, Sumpio BE, Shyy JY, Chien S. (1999) Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress. Journal of Clinical Investigation.103:1141-50.

11. Chen KD, Li YS, Kim M, Li S, Yuan S, Chien S, Shyy JYJ. (1999) Mechanotransduction in response to shear stress - Roles of receptor tyrosine kinases, integrins, and Shc. Journal of Biological Chemistry.274:18393-18400.

10. Hu YL, Li S, Shyy JYJ, Chien S. (1999) Sustained JNK activation induces endothelial apoptosis: studies with colchicine and shear stress. American Journal of Physiology-Heart and Circulatory Physiology.277:H1593-H1599.

9. Karlon WJ, Hsu PP, Li S, Chien S, McCulloch AD, Omens JH. (1999) Measurement of orientation and distribution of cellular alignment and cytoskeletal organization. Ann Biomed Eng.27:712-20.

8. Li S, Chien S, Branemark PI. (1999) Heat shock-induced necrosis and apoptosis in osteoblasts. J Orthop Res.17:891-9.

7. Chien S, Li S, Shyy JYJ. (1998) Effects of mechanical forces on signal transduction and gene expression in endothelial cells. Hypertension.31:162-169.

6. Jalali S, Li YS, Sotoudeh M, Yuan S, Li S, Chien S, Shyy JY. (1998) Shear stress activates p60src-Ras-MAPK signaling pathways in vascular endothelial cells. Arterioscler Thromb Vasc Biol.18:227-34.

5. Li S, Kim M, Hu YL, Jalali S, Schlaepfer DD, Hunter T, Chien S, Shyy JYJ. (1997) Fluid shear stress activation of focal adhesion kinase - Linking to mitogen-activated protein kinases. Journal of Biological Chemistry.272:30455-30462.

4. Li S, Piotrowicz RS, Levin EG, Shyy YJ, Chien S. (1996) Fluid shear stress induces the phosphorylation of small heat shock proteins in vascular endothelial cells. Am J Physiol:C994-1000.

3. Li YS, Shyy JY, Li S, Lee J, Su B, Karin M, Chien S. (1996) The Ras-JNK pathway is involved in shear-induced gene expression. Mol Cell Biol.16:5947-54.

2. Li S, Wen GB, Yan ZY, Tao ZL. (1993) Three-dimensional analysis of the concentration in an electrophoresis chamber with continuous flow. Acta Mechanica Sinica.25:29-39.

1. Wen GB, Li S. (1990) Effect of endothelial cell shape on arterial macromolecular transport. Acta Scientiarum Naturalium, Universitantis Pekanis.26:58-70.